Conformational analyses of thiirane-based gelatinase inhibitors
نویسندگان
چکیده
منابع مشابه
N-substituted homopiperazine barbiturates as gelatinase inhibitors.
Matrix metalloproteinases are implicated in a wide range of pathophysiological processes and potent selective inhibitors for these enzymes continue to be eagerly sought. 5,5-Disubstituted barbiturates hold promise as inhibitor types being stable in vivo and relatively selective for the gelatinases (MMP-2 and MMP-9). In this paper we describe the synthesis of 5-piperazine and -homopiperazine sub...
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Taking into account the thiophilic properties of iodine, a very simple methodology to achieve 2 0,3 0-didehydro-2 0,3 0-dideoxy-b-nucleosides in high yield was performed, using mild, and inexpensive conditions, by means of the treatment of 2 0-deoxy-3 0,5 0dibenzoyl-2 0-iodo-b-nucleoside derivatives with NaHS. The process has shown to be highly dependent of the relative geometry between the iod...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2008
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2007.11.131